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In fact, virtually all the antidepressant drugs that have relieved neuropathic pain in placebo-controlled trials — amitriptyline, 2 , 3 , 13 desipramine, 11 , 12 nortriptyline, 33 imipramine, 34 and clomipramine 35 —block the reuptake of norepinephrine or have an active metabolite that does so. To enhance survival, the adrenals force a down-regulation of energy production. A defendant is charged with a heavier burden of proof in showing a pre-indictment delay due process violation than in showing a denial of his speedy trial rights?

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